Milk may do a body good.
نویسندگان
چکیده
The radiolabelled opioid receptor binding affinities of morphine and its active metabolite morphine 6-glucuronide at the total mu, mu 1, mu 2 and delta receptors were determined. Morphine 6-glucuronide was found to have a 4-fold lower affinity for the mu 2 receptor (IC50 17 nm and 82 nm for morphine and morphine 6-glucuronide respectively, P = 0.01), the receptor postulated to be responsible for mediating the respiratory depression and gastrointestinal effects after morphine. This provides a possible explanation for the reduced respiratory depression and vomiting seen following morphine 6-glucuronide in man. A similar reduction in affinity of morphine 6-glucuronide was seen at the total mu receptor whilst there was no significant difference seen at the mu or delta receptor. Hence the increased analgesic potency of morphine 6-glucuronide over morphine remains unexplained.
منابع مشابه
Calcium, milk, and osteoporosis
Make no bones about it ? milk is an excellent source of calcium! There may be some downsides to guzzling milk, such as lactose intolerance or a hefty grocery bill, but there seems to be a few schools of thought when it comes to its impact on calcium loss (more on that in a bit). To build strong bones and ward off osteoporosis, milk (and calcium supplements [2] to some extent) can do the body go...
متن کاملCalcium, milk, and osteoporosis
Make no bones about it ? milk is an excellent source of calcium! There may be some downsides to guzzling milk, such as lactose intolerance or a hefty grocery bill, but there seems to be a few schools of thought when it comes to its impact on calcium loss (more on that in a bit). To build strong bones and ward off osteoporosis, milk (and calcium supplements [2] to some extent) can do the body go...
متن کاملCalcium, milk, and osteoporosis
Make no bones about it ? milk is an excellent source of calcium! There may be some downsides to guzzling milk, such as lactose intolerance or a hefty grocery bill, but there seems to be a few schools of thought when it comes to its impact on calcium loss (more on that in a bit). To build strong bones and ward off osteoporosis, milk (and calcium supplements [2] to some extent) can do the body go...
متن کاملCalcium, milk, and osteoporosis
Make no bones about it ? milk is an excellent source of calcium! There may be some downsides to guzzling milk, such as lactose intolerance or a hefty grocery bill, but there seems to be a few schools of thought when it comes to its impact on calcium loss (more on that in a bit). To build strong bones and ward off osteoporosis, milk (and calcium supplements [2] to some extent) can do the body go...
متن کاملCalcium, milk, and osteoporosis
Make no bones about it ? milk is an excellent source of calcium! There may be some downsides to guzzling milk, such as lactose intolerance or a hefty grocery bill, but there seems to be a few schools of thought when it comes to its impact on calcium loss (more on that in a bit). To build strong bones and ward off osteoporosis, milk (and calcium supplements [2] to some extent) can do the body go...
متن کاملCalcium, milk, and osteoporosis
Make no bones about it ? milk is an excellent source of calcium! There may be some downsides to guzzling milk, such as lactose intolerance or a hefty grocery bill, but there seems to be a few schools of thought when it comes to its impact on calcium loss (more on that in a bit). To build strong bones and ward off osteoporosis, milk (and calcium supplements [2] to some extent) can do the body go...
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ورودعنوان ژورنال:
- Environmental Health Perspectives
دوره 103 شماره
صفحات -
تاریخ انتشار 1995