Milk may do a body good.

نویسندگان

  • D. Hucks
  • P. I. Thompson
  • A. Grossman
  • L. H. Rees
چکیده

The radiolabelled opioid receptor binding affinities of morphine and its active metabolite morphine 6-glucuronide at the total mu, mu 1, mu 2 and delta receptors were determined. Morphine 6-glucuronide was found to have a 4-fold lower affinity for the mu 2 receptor (IC50 17 nm and 82 nm for morphine and morphine 6-glucuronide respectively, P = 0.01), the receptor postulated to be responsible for mediating the respiratory depression and gastrointestinal effects after morphine. This provides a possible explanation for the reduced respiratory depression and vomiting seen following morphine 6-glucuronide in man. A similar reduction in affinity of morphine 6-glucuronide was seen at the total mu receptor whilst there was no significant difference seen at the mu or delta receptor. Hence the increased analgesic potency of morphine 6-glucuronide over morphine remains unexplained.

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Calcium, milk, and osteoporosis

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Calcium, milk, and osteoporosis

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عنوان ژورنال:
  • Environmental Health Perspectives

دوره 103  شماره 

صفحات  -

تاریخ انتشار 1995